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Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women

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Title: Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women
Author(s): Klempel, Monica C; Kroeger, Cynthia M; Bhutani, Surabhi; Trepanowski, John F; Varady, Krista A
Subject(s): Intermittent fasting Calorie restriction Liquid diet Body Weight Visceral fat
Abstract: Background: Intermittent fasting (IF; severe restriction 1 d/week) facilitates weight loss and improves coronary heart disease (CHD) risk indicators. The degree to which weight loss can be enhanced if IF is combined with calorie restriction (CR) and liquid meals, remains unknown. Objective: This study examined the effects of IF plus CR (with or without a liquid diet) on body weight, body composition, and CHD risk. Methods: Obese women (n = 54) were randomized to either the IFCR-liquid (IFCR-L) or IFCR-food based (IFCR-F) diet. The trial had two phases: 1) 2-week weight maintenance period, and 2) 8-week weight loss period. Results: Body weight decreased more (P = 0.04) in the IFCR-L group (3.9 +/- 1.4 kg) versus the IFCR-F group (2.5 +/- 0.6 kg). Fat mass decreased similarly (P < 0.0001) in the IFCR-L and IFCR-F groups (2.8 +/- 1.2 kg and 1.9 +/- 0.7 kg, respectively). Visceral fat was reduced (P < 0.001) by IFCR-L (0.7 +/- 0.5 kg) and IFCR-F (0.3 +/- 0.5 kg) diets. Reductions in total and LDL cholesterol levels were greater (P = 0.04) in the IFCR-L (19 +/- 10%; 20 +/- 9%, respectively) versus the IFCR-F group (8 +/- 3%; 7 +/- 4%, respectively). LDL peak particle size increased (P < 0.01), while heart rate, glucose, insulin, and homocysteine decreased (P < 0.05), in the IFCR-L group only. Conclusion: These findings suggest that IF combined with CR and liquid meals is an effective strategy to help obese women lose weight and lower CHD risk.
Issue Date: 2012-11
Publisher: BioMed Central
Citation Info: Klempel MC, Kroeger CM, Bhutani S, Trepanowski JF, Varady KA. Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women. Nutrition Journal. Nov 2012;11. DOI: 10.1186/1475-2891-11-98
Type: Article
Description: © 2012 Klempel et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The original version is available through BioMed Central at DOI: 10.1186/1475-2891-11-98.
URI: http://hdl.handle.net/10027/10866
ISSN: 1475-2891
Date Available in INDIGO: 2013-12-06
 

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