INDIGO Home University of Illinois at Urbana-Champaign logo uic building uic pavilion uic student center

Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models

Show full item record

Bookmark or cite this item: http://hdl.handle.net/10027/19442

Files in this item

File Description Format
PDF Utilizing past and present.pdf (2MB) Main Article PDF
Title: Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models
Author(s): DeCant, B.T.; Principe, D.R.; Guerra, C.; Pasca di Magliano, M.; Grippo, P.J.
Subject(s): mouse model pancreatic cancer inducible conditional FLP/FRT Kras
Abstract: The study of pancreatic cancer has prompted the development of numerous mouse models that aim to recapitulate the phenotypic and mechanistic features of this deadly malignancy. This review accomplishes two tasks. First, it provides an overview of the models that have been used as representations of both the neoplastic and carcinoma phenotypes. Second, it presents new modeling schemes that ultimately will serve to more faithfully capture the temporal and spatial progression of the human disease, providing platforms for improved understanding of the role of non-epithelial compartments in disease etiology as well as evaluating therapeutic approaches.
Issue Date: 2014-12-04
Publisher: Frontiers
Citation Info: Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models. Frontiers in Physiology. 2014. 5. DOI: 10.3389/fphys.2014.00464.
Type: Article
Description: This is a copy of an article published in Frontiers in Physiology © 2014 Frontiers Publications.
URI: http://hdl.handle.net/10027/19442
ISSN: 1664-042X
Sponsor: None
Date Available in INDIGO: 2015-05-18
 

This item appears in the following Collection(s)

Show full item record

Statistics

Country Code Views
United States of America 202
China 104
Germany 33
Russian Federation 26
Ukraine 6

Browse

My Account

Information

Access Key