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BTLA exhibits immune memory for αβ T cells in patients with active pulmonary tuberculosis

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Title: BTLA exhibits immune memory for αβ T cells in patients with active pulmonary tuberculosis
Author(s): Zeng, J-C; Lin, D-Z; Yi, L-L; Lui, G-B; Zhang, H.; Wang, W-D; Zhang, J-A
Subject(s): Human active pulmonary tuberculosis B and T lymphocyte attenuator memory T cells, αβ T cells
Abstract: Despite past extensive studies, the role of B and T lymphocyte attenuator (BTLA) in αβ T cells in patients with active pulmonary tuberculosis (ATB) remains poorly understood. Here we demonstrate that BTLA expression on αβ T cells is decreased in patients with M. tuberculosis (Mtb) infection. Particularly, BTLA expression levels are likely critical for αβ T cells to manifest and maintain an active central memory phenotype with high capacity for secretion of IFN-γ and perforin, which are important for immune memory against TB infection. BTLAhigh αβ T cells also exhibited higher capacity in response to Mtb peptide stimulation. In contrast to the role of BTLA played for negative regulation of immune responses, our data in the current studies suggest that BTLA expression on αβ T cells is likely associated with protective immune memory against Mtb infection in the setting of patients with active pulmonary tuberculosis. This previous unappreciated role for BTLA may have implications for prevention and treatment of patients with Mtb infection.
Issue Date: 2014-10-15
Publisher: e-Century Publishing
Citation Info: Zeng, J. C., Lin, D. Z., Yi, L. L., Liu, G. B., Zhang, H., Wang, W. D., Zhang, J. A., Wu, X. J., Xiang, W. Y., Kong, B., Chen, Z. W., Wang, C. Y. and Xu, J. F. BTLA exhibits immune memory for αβ T cells in patients with active pulmonary tuberculosis. American Journal of Translational Research. 2014. 6(5): 494-506.
Type: Article
Description: This is a copy of an article published in the American Journal of Translational Research © 2014 e-Century Publishing.
URI: http://hdl.handle.net/10027/19963
ISSN: 1943-8141
Sponsor: We thank the nurses, doctors and staff at the Guangdong Medical College and Dongguan Hospital for Prophylaxis and Treatment of Chronic Disease for collection of study subjects and clinical data. This work was supported by the National Natural Science Foundation of China (81273237, 30972779), the Department of Science and Technology of Guangdong Province (2011B061300098), the Key Project of Science and Technology Innovation of Education Department of Guangdong Province (2012KJCX0059), the Science and Technology Project of Dongguan (2012105102016, 2013- 1051010006) , the Science and Technology Project of Zhanjiang (2013C03012) and the Science and Technology Innovation Fund of Guangdong Medical College (STIF201110, B20- 12078).
Date Available in INDIGO: 2016-01-13
 

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