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Basal Autophagy Is Required for Herpes simplex Virus-2 Infection.

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Title: Basal Autophagy Is Required for Herpes simplex Virus-2 Infection.
Author(s): Yakoub, AM; Shukla, D.
Abstract: Autophagy is a conserved catabolic process of the cell, which plays an important role in regulating plethora of infections. The role of autophagy in Herpes simplex virus-2 (HSV-2) infection is unknown. Here, we found that HSV-2 does not allow induction of an autophagic response to infection, but maintains basal autophagy levels mostly unchanged during productive infection. Thus, we investigated the importance of basal autophagy for HSV-2 infection, using pharmacological autophagy suppression or cells genetically deficient in an autophagy-essential gene (ATG5). Interference with basal autophagy flux in cells significantly reduced viral replication and diminished the infection. These results indicate that basal autophagy plays an indispensable role required for a productive infection. Importantly, this study draws a sharp distinction between induced and basal autophagy, where the former acts as a viral clearance mechanism abrogating infection, while the latter supports infection.
Issue Date: 2015-08-07
Publisher: Nature Publishing Group
Citation Info: Yakoub, A. M. and Shukla, D. Basal Autophagy Is Required for Herpes simplex Virus-2 Infection. Scientific Reports. 2015. 5. DOI: 10.1038/srep12985.
Type: Article
Description: This is the copy of an article published in Scientific Reports © 2015 Nature Publishing Group Publications. © The Author(s).
URI: http://hdl.handle.net/10027/20049
ISSN: 2045-2322
Sponsor: This study was supported by a NIH grant (EY023058) to D.S. and a core grant (EY01792). The authors claim no conflicts of interest.
Date Available in INDIGO: 2016-01-27
 

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