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Diet-Induced Changes in n-3- and n-6-Derived Endocannabinoids and Reductions in Headache Pain and Psychological Distress.

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Title: Diet-Induced Changes in n-3- and n-6-Derived Endocannabinoids and Reductions in Headache Pain and Psychological Distress.
Author(s): Ramsden, CE; Zamora, D.; Makriyannis, A.; Wood, JT; Mann, JD; Faurot, KR; MacIntosh, BA; Majchrzak-Hong, SF; Gross, JR; Courville, AB; Davis, JM; Hibbeln, JR
Subject(s): 2-arachidonoylglycerol 2-docosahexaenoylglycerol Endocannabinoids docosahexaenoylethanolamine headache psychological distress
Abstract: Omega-3 and omega-6 fatty acids are biosynthetic precursors of endocannabinoids with antinociceptive, anxiolytic, and neurogenic properties. We recently reported that targeted dietary manipulation-increasing omega-3 fatty acids while reducing omega-6 linoleic acid (the H3-L6 intervention)-reduced headache pain and psychological distress among chronic headache patients. It is not yet known whether these clinical improvements were due to changes in endocannabinoids and related mediators derived from omega-3 and omega-6 fatty acids. We therefore used data from this trial (N = 55) to investigate 1) whether the H3-L6 intervention altered omega-3- and omega-6-derived endocannabinoids in plasma and 2) whether diet-induced changes in these bioactive lipids were associated with clinical improvements. The H3-L6 intervention significantly increased the omega-3 docosahexaenoic acid derivatives 2-docosahexaenoylglycerol (+65%, P < .001) and docosahexaenoylethanolamine (+99%, P < .001) and reduced the omega-6 arachidonic acid derivative 2-arachidonoylglycerol (-25%, P = .001). Diet-induced changes in these endocannabinoid derivatives of omega-3 docosahexaenoic acid, but not omega-6 arachidonic acid, correlated with reductions in physical pain and psychological distress. These findings demonstrate that targeted dietary manipulation can alter endocannabinoids derived from omega-3 and omega-6 fatty acids in humans and suggest that 2-docosahexaenoylglycerol and docosahexaenoylethanolamine could have physical and/or psychological pain modulating properties. TRIAL REGISTRATION: ClinicalTrials.gov (NCT01157208) PERSPECTIVE: This article demonstrates that targeted dietary manipulation can alter endocannabinoids derived from omega-3 and omega-6 fatty acids and that these changes are related to reductions in headache pain and psychological distress. These findings suggest that dietary interventions could provide an effective, complementary approach for managing chronic pain and related conditions
Issue Date: 2015-08
Publisher: Elsevier
Citation Info: Ramsden, Christopher E., et al. "Diet-induced changes in n-3-and n-6-derived endocannabinoids and reductions in headache pain and psychological distress." The Journal of Pain 16.8 (2015): 707-716. DOI: 10.1016/j.jpain.2015.04.007.
Type: Article
Description: This is the copy of an article published in the Journal of Pain © 2015 Elsevier Publications. http://dx.doi.org/10.1016/j.jpain.2015.04.007
URI: http://hdl.handle.net/10027/20286
ISSN: 1526-5900
Sponsor: Supported by the Mayday Fund (primary funding source); the UNC Research Fellowship in Complementary and Alternative Medicine (grant T32-AT003378, NCCAM, NIH); the North Carolina Clinical and Translational Sciences Institute (grant UL1RR025747, NCRR, NIH); the UNC Nutrition Obesity Research Center, CHAI Core (grant DK056350, NIDDK, NIH); the National Institute on Drug Abuse (DA07215 and DA09158); and the Intramural Program of the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health.
Date Available in INDIGO: 2016-03-04
 

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