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CD11C antigen presenting cells with high B7-H4 expression in active tuberculosis patients are associated with low stimulatory capacity to T cell proliferation.

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Title: CD11C antigen presenting cells with high B7-H4 expression in active tuberculosis patients are associated with low stimulatory capacity to T cell proliferation.
Author(s): Wang, WD; Liu, GB; Zhang, JA; Lu, YB; Gao, YC; Dai, YC; Yu, SY; Jia, Y; Fu, XX; Chen, Z; Qiu, F; Yi, LL; Chen, ZW; Zhong, J; Xu, JF
Subject(s): B7-H4 CD11c APCs stimulatory capacity T cell proliferation tuberculosis
Abstract: B7-H4 is a co-inhibitory molecule that negatively regulates T lymphocytes, playing a role in immune suppression many disorders. However, the role of antigen presenting cells (APCs)-expressing B7-H4 in active pulmonary tuberculosis (ATB) remains poorly understood. Here, we demonstrated that B7-H4 expression on CD11c APCs increased in patients with ATB. B7-H4 expression on CD11c APCs was associated with high expression of HLA-DR and CD86 both in healthy controls (HCs) and in ATB patients. However, CD86 expression in B7-H4-expressing CD11c APCs was significantly lower in ATB patients compared to that in HCs. Importantly, B7-H4 expressing CD11c APCs from ATB patients showed a lower stimulatory capacity to T cell proliferation than those from HCs in mixed leukocyte culture test. Collectively, our data suggest that the evaluation of B7-H4 expression in CD11c APCs in patients with active tuberculosis might be one of the key molecular mechanisms for the dysfunction of APCs in TB patients. B7-H4 may have important implications in the prevention and treatment of patients with ATB.
Issue Date: 2016-03-30
Publisher: e-Century Publishing
Citation Info: Wang, W. D., Liu, G. B., Zhang, J. A., Lu, Y. B., Gao, Y. C., Dai, Y. C., Yu, S. Y., Jia, Y., Fu, X. X., Chen, Z., Qiu, F., Yi, L. L., Chen, Z. W., Zhong, J. and Xu, J. F. CD11C antigen presenting cells with high B7-H4 expression in active tuberculosis patients are associated with low stimulatory capacity to T cell proliferation. International Journal of Clinical and Experimental Medicine. 2016. 9(3): 7008-7017. DOI: 10.1002/9781118345313
Type: Article
Description: This is a copy of an article published in the International Journal of Clinical and Experimental Medicine © 2016 e-Century Publishing.
URI: http://hdl.handle.net/10027/20747
Sponsor: This work was supported by the National Natural Science Foundation of China (81273237, 81570009), Natural Science Foundation of Guangdong Province (2015A030313513), the Key Project of Science and Technology Innovation of Education Department of Guangdong Province (2012KJCX0059), the Science and Technology Project of Dongguan (2012105102016, 2014108101018) and the Science and Technology Innovation Fund of Guangdong Medical College (STIF201110, B2012078).
Date Available in INDIGO: 2016-06-13
 

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