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Elevated serum IL-35 and increased expression of IL-35-p35 or -EBI3 in CD4(+)CD25(+) T cells in patients with active tuberculosis.

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Title: Elevated serum IL-35 and increased expression of IL-35-p35 or -EBI3 in CD4(+)CD25(+) T cells in patients with active tuberculosis.
Author(s): Kong, B; Liu, GB; Zhang, JA; Fu, XX; Xiang, WY; Gao, YC; Lu, YB; Wu, XJ; Qiu, F; Wang, WD; Yi, LL; Zhong, JX; Chen, ZW; Xu, JF
Subject(s): CD4+CD25+ T cells EBI3 Human active pulmonary tuberculosis interleukin-35 p35
Abstract: Despite the recent appreciation of interleukin 35 (IL-35) function in inflammatory diseases, little is known for IL-35 response in patients with active tuberculosis (ATB). In the current study, we demonstrated that ATB patients exhibited increases in serum IL-35 and in mRNA expression of both subunits of IL-35 (p35 and EBI3) in white blood cells and peripheral blood mononuclear cells. Consistently, anti-TB drug treatment led to reduction in serum IL-35 level and p35 or EBI3 expression. TB infection was associated with expression of p35 or EBI3 protein in CD4(+) but not CD8(+) T cells. Most p35(+)CD4(+) T cells and EBI3(+)CD4(+) T cells expressed Treg-associated marker CD25. Our findings may be important in understanding immune pathogenesis of TB. IL-35 in the blood may potentially serve as a biomarker for immune status and prognosis in TB.
Issue Date: 2016-02-15
Publisher: e-Century Publishing
Citation Info: Kong, B., Liu, G. B., Zhang, J. A., Fu, X. X., Xiang, W. Y., Gao, Y. C., Lu, Y. B., Wu, X. J., Qiu, F., Wang, W. D., Yi, L. L., Zhong, J. X., Chen, Z. W. and Xu, J. F. Elevated serum IL-35 and increased expression of IL-35-p35 or-EBI3 in CD4(+)CD25(+) T cells in patients with active tuberculosis. American Journal of Translational Research. 2016. 8(2): 623-633.
Type: Article
Description: This is a copy of an article published in the American Journal of Translational Research © 2016 e-Century Publishing Publications.
URI: http://hdl.handle.net/10027/21046
Sponsor: This work was supported by grants from the National Natural Science Foundation of China (81570009, 81273237, 30972779, 81101553), Natural Science Foundation of Guangdong Province (2015A030313513), the Key Project of Science and Technology Innovation of Education Department of Guangdong Province (2012KJCX0059), the Science and Technology Project of Dongguan (201450715200503), the Science and Technology Project of Zhanjiang (2013C03012) and the Science and Technology Innovation Fund of GDMC (STIF201110, B2012078).
Date Available in INDIGO: 2016-08-08
 

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