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Proposed mechanism for lipoprotein remodelling in the brain

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Title: Proposed mechanism for lipoprotein remodelling in the brain
Author(s): Yu, Chunjiang; Youmans, Katherine L.; LaDu, Mary J.
Subject(s): Lipoproteins
Abstract: Lipoprotein remodelling in the periphery has been extensively studied. For example, the processing of nascent apoAI particles to cholesterol-loaded HDL lipoproteins during reverse cholesterol transport involves a series of enzymes, transporters in peripheral tissue, as well as other apolipoproteins and lipoproteins. These extensive modifications and interconversions are well defined. Here, we present the hypothesis that a similar process occurs within the blood brain barrier (BBB) via glia-secreted lipid-poor apoE particles undergoing remodelling to become mature central nervous system (CNS) lipoproteins. We further pose several pressing issues and future directions for the study of lipoproteins in the brain.
Issue Date: 2010-08
Publisher: Elsevier
Citation Info: Yu, C., Youmans, K. L., & Ladu, M. J. 2010. Proposed mechanism for lipoprotein remodelling in the brain. Biochimica et Biophysica Acta, 1801(8): 819-823. DOI: 10.1016/j.bbalip.2010.05.001
Type: Article
Description: Postprint version of article may differ from published version. The definitive version is available through Elsevier at DOI: 10.1016/j.bbalip.2010.05.001
ISSN: 1388-1981
Date Available in INDIGO: 2011-01-10

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