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Do inflammatory cells influence skeletal muscle hypertrophy?

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Title: Do inflammatory cells influence skeletal muscle hypertrophy?
Author(s): Koh, Timothy; Pizza, Francis
Subject(s): skeletal muscle hypertrophy mechanical loading inflammatory response inflammatory cells
Abstract: Most research on muscle hypertrophy has focused on the responses of muscle cells to mechanical loading; however, a number of studies also suggest that inflammatory cells may influence muscle hypertrophy. Neutrophils and macrophages accumulate in skeletal muscle following increased mechanical loading, and we have demonstrated that macrophages are essential for hypertrophy following synergist ablation. Whether neutrophils are required remains to be determined. Non-steroidal anti-inflammatory drugs impair adaptive responses of skeletal muscle in both human and animal experiments suggesting that the routine use of such drugs could impair muscle performance. Much remains to be learned about the role of inflammatory cells in muscle hypertrophy, including the molecular signals involved in calling neutrophils and macrophages to skeletal muscle as well as those that regulate their function in muscle. In addition, although we have demonstrated that macrophages produce growth promoting factors during muscle hypertrophy, the full range of functional activities involved in muscle hypertrophy remains to be determined. Further investigation should provide insight into the intriguing hypothesis that inflammatory cells play integral roles in regulating muscle hypertrophy.
Issue Date: 2009-06-01
Publisher: Frontiers in Bioscience
Citation Info: Koh, T. J. & Pizza, F. X. 2009. Do inflammatory cells influence skeletal muscle hypertrophy? Frontiers in Bioscience, 1: 60-71.
Type: Article
Description: Post print version of article may differ from published version. The definitive version is available through Frontiers in Bioscience at
ISSN: 1945-0508
Date Available in INDIGO: 2011-03-01

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