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Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague-Dawley rats

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Title: Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague-Dawley rats
Author(s): Prins, Gail S.; Ye, Shu-Hua; Birch, Lynn; Ho, Shuk-mei; Kannan, Kurunthachalam
Subject(s): prostate pharmacokinetics
Abstract: The present study examines BPA pharmacokinetics in neonatal rats following s.c. injection or oral delivery of 10g BPA/kg BW and compares susceptibility to estrogen-induced prostate intraepithelial neoplasia (PIN) following either exposure route. Serum BPA in PND3 rats was measured using HPLC-MS-MS. Free and total BPA at Cmax were 1.77 and 2.0 ng/ml, respectively following injection and 0.26 and 1.02 ng/ml, respectively following oral exposure. The AUC0-2 for free and total BPA was 4.1- fold and 1.8-fold greater, respectively, in s.c. versus oral delivery. While exposure route affected BPA metabolism, internal dosimetry following s.c. injection of 10g BPA/kg BW is similar to BPA levels observed in humans. Prostates from aged rats given s.c. or oral BPA neonatally and T+E implants as adults exhibited nearly identical, heightened susceptibility to PIN incidence and score as compared to neonatal oil-controls. These findings on prostate health are directly relevant to humans at current BPA exposure levels.
Issue Date: 2011-01-31
Publisher: Elsevier
Citation Info: Prins, G. S., Ye, S. H., Birch, L., Ho, S. M., & Kannan, K. 2010. Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague-Dawley rats. Reproductive Toxicology. DOI: 10.1016/j.reprotox.2010.09.009
Type: Article
Description: Post print version of article may differ from published version. The definitive version is available through Elsevier at DOI: 10.1016/j.reprotox.2010.09.009
URI: http://hdl.handle.net/10027/7554
ISSN: 1873-1708
Sponsor: Supported by NIH grant ES-015584 with supplemental NIH funding from American Recovery and Reinvestment Act.
Date Available in INDIGO: 2011-04-29
 

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