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Sarcomere Control Mechanisms and the Dynamics of the Cardiac Cycle

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Title: Sarcomere Control Mechanisms and the Dynamics of the Cardiac Cycle
Author(s): Solaro, R. John
Subject(s): sacromeres cardiac cycle
Abstract: This review focuses on recent developments in the molecular mechanisms by which Ca activates cardiac sarcomeres and how these mechanisms play out in the cardiac cycle. I emphasize the role of mechanisms intrinsic to the sarcomeres as significant determinants of systolic elastance and ventricular stiffening during ejection. Data are presented supporting the idea that processes intrinsic to the thin filaments may promote cooperative activation of the sarcomeres and be an important factor in maintaining and modifying systolic elastance. Application of these ideas to translational medicine and rationale drug design forms an important rationale for detailed understanding of these processes.
Issue Date: 2010
Publisher: Hindawi Publishing Corporation
Citation Info: Solaro, R. J. 2010. Sarcomere Control Mechanisms and the Dynamics of the Cardiac Cycle. Journal of Biomedicine and Biotechnology. DOI: 10.1155/2010/105648
Type: Article
Description: The original source for this publication is at Hindawi Publishing Corporation; DOI: 10.1155/2010/105648
URI: http://hdl.handle.net/10027/7571
ISSN: 1110-7243
Sponsor: Support from NIH grants PO1 HL 62426, RO1 HL 22231, and RO1 HL 64035.
Date Available in INDIGO: 2011-05-05
 

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