INDIGO Home University of Illinois at Urbana-Champaign logo uic building uic pavilion uic student center

Intravenous lipid emulsion in clinical toxicology

Show simple item record

Bookmark or cite this item: http://hdl.handle.net/10027/7599

Files in this item

File Description Format
PDF 1757-7241-18-51.pdf (443KB) (no description provided) PDF
Title: Intravenous lipid emulsion in clinical toxicology
Author(s): Rothschild, Leelach; Bern, Sarah; Oswald, Sarah; Weinberg, Guy
Subject(s): Intravenous lipid emulsion anesthetic-induced cardiovascular collapse
Abstract: Intravenous lipid emulsion is an established, effective treatment for local anesthetic-induced cardiovascular collapse. The predominant theory for its mechanism of action is that by creating an expanded, intravascular lipid phase, equilibria are established that drive the offending drug from target tissues into the newly formed ‘lipid sink’. Based on this hypothesis, lipid emulsion has been considered a candidate for generic reversal of toxicity caused by overdose of any lipophilic drug. Recent case reports of successful resuscitation suggest the efficacy of lipid emulsion infusion for treating non-local anesthetic overdoses across a wide spectrum of drugs: beta blockers, calcium channel blockers, parasiticides, herbicides and several varieties of psychotropic agents. Lipid emulsion therapy is gaining acceptance in emergency rooms and other critical care settings as a possible treatment for lipophilic drug toxicity. While protocols exist for administration of lipid emulsion in the setting of local anesthetic toxicity, no optimal regimen has been established for treatment of acute non-local anesthetic poisonings. Future studies will shape the evolving recommendations for lipid emulsion in the setting of non-local anesthetic drug overdose.
Issue Date: 2010-10-05
Publisher: BioMed Central
Citation Info: Rothschild, L., Bern, S., Oswald, S., & Weinberg, G. 2010. Intravenous lipid emulsion in clinical toxicology. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 18(1): 51. DOI: 10.1186/1757-7241-18-51
Type: Article
Description: The original version is available through BioMed Central at DOI: 10.1186/1757-7241-18-51. © 2010 Rothschild et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/10027/7599
ISSN: 1757-7241
Date Available in INDIGO: 2011-05-11
 

This item appears in the following Collection(s)

Show simple item record

Statistics

Country Code Views
United States of America 108
China 21
United Kingdom 7
Denmark 1
Netherlands 1

Browse

My Account

Information

Access Key