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Dietary and physical activity adaptations to alternate day modified fasting: implications for optimal weight loss

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Title: Dietary and physical activity adaptations to alternate day modified fasting: implications for optimal weight loss
Author(s): Klempel, Monica C.; Bhutani, Surabhi; Fitzgibbon, Marian; Freels, Sally; Varady, Krista A.
Subject(s): body weight weight loss
Abstract: Background Alternate day modified fasting (ADMF) is an effective strategy for weight loss in obese adults. Objective The objective of this study was to examine the dietary and physical activity adaptations that occur during short-term ADMF, and to determine how these modulations affect rate of weight loss. Methods Sixteen obese subjects (12 women/4 men) completed a 10-week trial consisting of 3 phases: 1) 2-week control phase, 2) 4-week ADMF controlled feeding phase, and 3) 4-week ADMF self-selected feeding phase. Results Body weight decreased (P < 0.001) by 5.6 ± 1.0 kg post-treatment. Energy intake on the fast day was 26 ± 3% of baseline needs (501 ± 28 kcal/d). No hyperphagic response occurred on the feed day (95 ± 6% of baseline needs consumed, 1801 ± 226 kcal/d). Daily energy restriction (37 ± 7%) was correlated to rate of weight loss (r = 0.42, P = 0.01). Dietary fat intake decreased (36% to 33% of kcal, P < 0.05) with dietary counseling, and was related to rate of weight loss (r = 0.38, P = 0.03). Hunger on the fast day decreased (P < 0.05) by week 2, and remained low. Habitual physical activity was maintained throughout the study (fast day: 6416 ± 851 steps/d; feed day: 6569 ± 910 steps/d). Conclusion These findings indicate that obese subjects quickly adapt to ADMF, and that changes in energy/macronutrient intake, hunger, and maintenance of physical activity play a role in influencing rate of weight loss by ADMF.
Issue Date: 2010-09-03
Publisher: BioMed Central
Citation Info: Klempel, M. C., Bhutani, S., Fitzgibbon, M., Freels, S., & Varady, K. A. 2010. Dietary and physical activity adaptations to alternate day modified fasting: implications for optimal weight loss. Nutrition Journal, 9: 35. DOI: 10.1186/1475-2891-9-35
Type: Article
Description: The original source for this publication is at BioMed Central; DOI: 10.1186/1475-2891-9-35. © 2010 Klempel et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/10027/7614
ISSN: 1475-2891
Sponsor: Funding source: University of Illinois at Chicago, Departmental funding.
Date Available in INDIGO: 2011-05-12
 

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