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Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis

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Title: Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis
Author(s): Villaflores, Oliver B.; Macabeo, Allan Patrick G.; Gehle, Dietmar; Krohn, Karsten; Franzblau, Scott G.; Aguinaldo, Alicia M.
Subject(s): tuberculosis purpurata
Abstract: Alpinia purpurata or red ginger was studied for its phytochemical constituents as part of our growing interest on Philippine Zingiberaceae plants that may exhibit antimycobacterial activity. The hexane and dichloromethane subextracts of the leaves were fractionated and purified using silica gel chromatography to afford a mixture of C-28-C-32 fatty alcohols, a 3-methoxyflavone and two steroidal glycosides. The two latter metabolites were spectroscopically identified as kumatakenin (1), sitosteryl-3-O-6-palmitoyl-beta-D-glucoside (2) and beta-sitosteryl galactoside (3) using ultraviolet (UV), infrared (IR), electron impact mass spectrometer (EIMS) and nuclear magnetic resonance (NMR) experiments, and by comparison with literature data. This study demonstrates for the first time the isolation of these constituents from A. purpurata. In addition to the purported anti-inflammatory activity, its phytomedicinal potential to treat tuberculosis is also described.
Issue Date: 2010-10-20
Publisher: Medknow Publications
Citation Info: Villaflores, O. B., Macabeo, A. P. G., Gehle, D., Krohn, K., Franzblau, S. G., & Aguinaldo, A. M. 2010. Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis. Pharmacognosy Magazine, 6(24): 339-344. DOI: 10.4103/0973-1296.71785.
Type: Article
Description: The original source for this publication is at Medknow Publications. DOI: 10.4103/0973-1296.71785
URI: http://hdl.handle.net/10027/7616
ISSN: 0973-1296
Sponsor: This study was supported by the Philippine Council for Advanced Science and Technology Research and Development, Department of Science and Technology, Manila, and by the Department of Chemistry, College of Science, University of Santo Tomas, Manila.
Date Available in INDIGO: 2011-05-12
 

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