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GTPases in intracellular trafficking: an overview.

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Title: GTPases in intracellular trafficking: an overview.
Author(s): Segev, Nava
Subject(s): GTPases vesicular transport
Abstract: Small GTPases that belong to the ras sub-families of Rab, Arf, and Rho, and the large GTPase dynamin, regulate intracellular trafficking. This issue of Seminars of Cell and Developmental Biology highlights topics regarding mechanisms by which these GTPases regulate the different steps of vesicular transport: vesicle formation, scission, targeting and fusion. In addition, the emerging roles of GTPases in coordination of individual transport steps as well as coordination of intracellular trafficking with other cellular processes are reviewed. Finally, common structures and mechanisms underlying the function of the ras-like GTPases and the importance of their function to human health and disease are discussed.
Issue Date: 2011-02
Publisher: Elsevier
Citation Info: Segev, N. 2010. GTPases in intracellular trafficking: An overview. Seminars in Cell and Developmental Biology. 22(1):1-2. DOI: 10.1016/j.semcdb.2010.12.004
Type: Article
Description: Post print version of article may differ from published version. The definitive version is available through Elsevier at DOI: 10.1016/j.semcdb.2010.12.004
ISSN: 1096-3634DOI: 10.1016/j.semcdb.2010.12.004
Date Available in INDIGO: 2011-05-25

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