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The insulin immunoassay after 50 years: a reassessment

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Title: The insulin immunoassay after 50 years: a reassessment
Author(s): Blumenthal, Stanley
Subject(s): radioimmunoassay plasma insulin
Abstract: In 1960 Berson and Yalow published a method for the radioimmunoassay (RIA) of plasma insulin based on the concept that the extent to which unlabeled insulin displaces labeled insulin from anti-insulin antibody is proportional to the concentration of unlabeled insulin. The RIA for insulin has greatly increased knowledge of the physiology of glucose homeostasis and of the diverse causes of diabetes mellitus. Beyond this, the insight on which the RIA—or,more broadly, the competitive protein-binding assay—is based has provided the means to measure nanomolar or picomolar concentrations of a vast array of compounds in plasma and tissues. Directly or indirectly, the RIA has profoundly affected every branch of medicine.This essay reviews the ideas that were current in the medical research community when Berson and Yalow began their work and the observations and reasoning process that led them to their seminal discovery.
Issue Date: 2009
Publisher: University of Chicago Press
Citation Info: Blumenthal, S. 2009. The insulin immunoassay after 50 years: a reassessment. Perspectives in Biology and Medicine, 52(3): 343-354. DOI: 10.1353/pbm.0.0091
Type: Article
Description: Post print version of article may differ from published version. The definitive version is available through University of Chicago Press at DOI: 10.1353/pbm.0.0091; © 2009 by The Johns Hopkins University Press
URI: http://hdl.handle.net/10027/7650
ISSN: 0031-5982
Date Available in INDIGO: 2011-05-25
 

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