INDIGO Home University of Illinois at Urbana-Champaign logo uic building uic pavilion uic student center

Potential treatment options and future research to increase hepatitis C virus treatment response rate

Show simple item record

Bookmark or cite this item: http://hdl.handle.net/10027/7703

Files in this item

File Description Format
PDF HMER-7193-poten ... arch-to-increase093010.pdf (1MB) (no description provided) PDF
Title: Potential treatment options and future research to increase hepatitis C virus treatment response rate
Author(s): Tencate, Veronica; Sainz, Bruno Jr.; Cotler, Scott J.; Uprichard, Susan L.
Subject(s): hepatitis treatment
Abstract: Hepatitis C virus (HCV) is a liver-tropic blood-borne pathogen that affects more than 170 million people worldwide. Although acute infections are usually asymptomatic, up to 90% of HCV infections persist with the possibility of long-term consequences such as liver fibrosis, cirrhosis, steatosis, insulin resistance, or hepatocellular carcinoma. As such, HCV-associated liver disease is a major public health concern. Although the currently available standard of care therapy of pegylated interferon α plus ribavirin successfully treats infection in a subset of patients, the development of more effective, less toxic HCV antivirals is a health care imperative. This review not only discusses the limitations of the current HCV standard of care but also evaluates upcoming HCV treatment options and how current research elucidating the viral life cycle is facilitating the development of HCV-specific therapeutics that promise to greatly improve treatment response rates both before and after liver transplantation.
Issue Date: 2010-10
Publisher: Dove Medical Press
Citation Info: Tencate, V., Sainz, B., Cotler, S. J., & Uprichard, S. L. 2010. Potential treatment options and future research to increase hepatitis C virus treatment response rate. Hepatic Medicine : Evidence and Research, 2010(2): 125-145. DOI: 10.2147/HMER.S7193
Type: Article
Description: The original source for this publication is at Dove Medical Press. DOI: 10.2147/HMER.S7193
URI: http://hdl.handle.net/10027/7703
ISSN: 1179-1535
Sponsor: Drs. Uprichard and Sainz were supported by National Institutes of Health grants AI070827 and CA33266 and American Cancer Society grant RSG-09-076-01. Drs. Uprichard and Cotler were supported by the UIC Walter Payton Center GUILD. Dr. TenCate was supported by an Institutional Ruth L. Kirchstein National Research Service Award (DK-007788-07) from the National Institute of Diabetes and Digestive and Kidney Diseases
Date Available in INDIGO: 2011-05-27
 

This item appears in the following Collection(s)

Show simple item record

Statistics

Country Code Views
United States of America 133
United Kingdom 19
China 18
Netherlands 2
Australia 1

Browse

My Account

Information

Access Key