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Aqueous and Vitreous Penetration of Linezolid and Levofloxacin After Oral Administration

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Title: Aqueous and Vitreous Penetration of Linezolid and Levofloxacin After Oral Administration
Author(s): George, Jomy M.; Fiscella, Richard; Blair, Michael; Rodvold, Keith; Ulanski, Lawrence; Stokes, John; Blair, Norman; Pontiggia, Laura
Subject(s): vitrectomy linezolid levofloxacin
Abstract: Purpose: To evaluate the time course of drug concentrations achieved in aqueous (AQ), vitreous (V), and serum (S) compartments after oral administration of linezolid and levofloxacin. Design: Randomized, clinical trial. Methods: Settings: Clinical practice. Patient population: Sixteen patients (16 eyes) undergoing vitrectomy who had not had a prior pars plana vitrectomy in the study eye were randomly assigned to one of 4 groups. Intervention: AQ, V, and S samples were obtained from all subjects after single concomitant doses of linezolid 600mg and levofloxacin 750mg between 1 and 12 h before the procedure: group A - 1-3 h; group B - 3-6 h; group C - 6-9 h; group D - 9-12 h. Main outcome measures: AQ, V, and S concentrations of linezolid and levofloxacin. Results: Overall mean concentrations +/- standard deviation (mu g/mL) achieved by linezolid in AQ, V, and S compartments were 3.32 +/- 2.06, 2.98 +/- 1.87, and 7.91 +/- 3.94, respectively. Overall mean concentrations +/- standard deviation (mu g/mL) achieved by levofloxacin in AQ, V, and S compartments were 2.19 +/- 1.92, 1.95 +/- 1.27, and 7.38 +/- 3.47, respectively. Conclusions: Single concomitant doses of linezolid and levofloxacin achieved AQ and V concentrations above the minimum inhibitory concentration for 90% of common ocular gram-positive and gram-negative pathogens up to 12 h after administration. The combination of linezolid and levofloxacin represents a viable option for the prophylaxis and management of endophthalmitis.
Issue Date: 2010-12
Publisher: Mary Ann Liebert
Citation Info: George, J. M., Fiscella, R., Blair, M., Rodvold, K., Ulanski, L., Stokes, J., Blair, N., & Pontiggia, L. 2010. Aqueous and Vitreous Penetration of Linezolid and Levofloxacin After Oral Administration. Journal of Ocular Pharmacology and Therapeutics, 26(6): 579-586. DOI: 10.1089/jop.2010.0022.
Type: Article
Description: This is a copy of an article published in the Journal of Ocular Pharmacology and Therapeutics © 2010 [copyright Mary Ann Liebert, Inc.]; Journal of Ocular Pharmacology and Therapeutics is available online at: http://www.liebertonline.com. DOI: 10.1089/jop.2010.0022
URI: http://hdl.handle.net/10027/7739
ISSN: 1080-7683
Date Available in INDIGO: 2011-05-27
 

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