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The curious role of sarcomeric proteins in control of diverse processes in cardiac myocytes

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Title: The curious role of sarcomeric proteins in control of diverse processes in cardiac myocytes
Author(s): Solaro, Ross John; Sheehan, Katherine A.; Lei, Ming; Ke, Yunbo
Subject(s): myocytes sacromeric proteins
Abstract: Introduction Relatively recent developments in our understanding of sarcomeric proteins have expanded their role from the home of molecular motors generating force and shortening to a cellular organelle fully integrated in the control of structural, electrical, mechanical, chemical, and metabolic homeostasis. Even so, in some cases these diverse functions of sarcomeric proteins appear to remain a curiosity, not fully appreciated in the analysis of major controllers of cardiac function. This attitude toward the function of sarcomeric proteins in cardiac myocytes is summarized in the following definition of “curiosity,” which seems particularly apropos: “meddlesome; thrusting oneself into and taking an active part in others’ affairs.” We focus in this Perspective on how sarcomeric proteins function in integration with membrane channels and transporters in control of cardiac dynamics, especially in adrenergic control of cardiac function. Understanding these mechanisms at the level of cardiac sarcomeres took on special significance with the identification of mutations in sarcomeric proteins as the most common cause of familial hypertrophic and dilated cardiomyopathies. These mutations commonly lead to structural, electrical, and metabolic remodeling and to sudden death. These disorders indicate a critical role of processes at the level of the sarcomeres in homeostatic control of cardiac energetics, dynamics, and structure. Yet, control of Ca2+ delivery to and removal from the myofilaments has dominated discussions of mechanisms regulating cardiac contractility. We first provide an alternative perspective in which rate processes at the level of the sarcomeres appear to be dominant during the rise and maintenance of systolic elastance and of isovolumic relaxation. A discussion of established adrenergic mechanisms and newly understood anti-adrenergic mechanisms controlling sarcomere response to Ca2+ follows and expands on this perspective.
Issue Date: 2010-07
Publisher: Rockefeller University Press
Citation Info: Solaro, R. J., Sheehan, K. A., Lei, M., & Ke, Y. 2010. The curious role of sarcomeric proteins in control of diverse processes in cardiac myocytes. Journal of General Physiology, 136(1): 13-19. DOI: 10.1085/jgp.201010462.
Type: Article
Description: © 2010 Solaro et al. This article is distributed under the terms of an Attribution–Noncommercial– Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). The original source for this publication is at Rockefeller University Press; DOI: 10.1085/jgp.201010462
URI: http://hdl.handle.net/10027/7745
ISSN: 0022-1295
Sponsor: Work described here is supported by grants from the National Institutes of Health (NHLBI RO1 HL 064035, RO1 HL 022231, and PO1 HL 062626 to R.J. Solaro) and by the Wellcome Trust n(to M. Lei).
Date Available in INDIGO: 2011-05-27
 

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