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Serum Bisphenol A Pharmacokinetics and Prostate Neoplastic Responses Following Oral and Subcutaneous Exposures in Neonatal Sprague-Dawley Rats

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Title: Serum Bisphenol A Pharmacokinetics and Prostate Neoplastic Responses Following Oral and Subcutaneous Exposures in Neonatal Sprague-Dawley Rats
Alternative Title: BPA Route of Exposure Analysis in Neonatal Rats
Author(s): Prins, Gail S.; Ye, Shu-Hua; Birch, Lynn; Ho, Shuk-mei; Kannan, Kurunthachalam
Subject(s): BPA bisphenol A prostate pharmacokinetics prostate intraepithelial neoplasia
Abstract: The present study examines BPA pharmacokinetics in neonatal rats following s.c. injection or oral delivery of 10g BPA/kg BW and compares susceptibility to estrogen-induced prostate intraepithelial neoplasia (PIN) following either exposure route. Serum BPA in PND3 rats was measured using HPLC-MS-MS. Free and total BPA at Cmax were 1.77 and 2.0 ng/ml, respectively following injection and 0.26 and 1.02 ng/ml, respectively following oral exposure. The AUC0-2 for free and total BPA was 4.1-fold and 1.8-fold greater, respectively, in s.c. versus oral delivery. While exposure route affected BPA metabolism, internal dosimetry following s.c. injection of 10g BPA/kg BW is similar to BPA levels observed in humans. Prostates from aged rats given s.c. or oral BPA neonatally and T+E implants as adults exhibited nearly identical, heightened susceptibility to PIN incidence and score as compared to neonatal oil-controls. These findings on prostate health are directly relevant to humans at current BPA exposure levels.
Issue Date: 2011-01
Publisher: Elsevier
Citation Info: Prins, G. S., Ye, S. H., Birch, L., Ho, S. M., & Kannan, K. 2010. Serum Bisphenol A Pharmacokinetics and Prostate Neoplastic Responses Following Oral and Subcutaneous Exposures in Neonatal Sprague-Dawley Rats. Reproductive Toxicology, 31(1):1-9. DOI: 10.1016/j.reprotox.2010.09.009
Type: Article
Description: NOTICE: this is the author’s version of a work that was accepted for publication in Reproductive Toxicology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Reproductive Toxicology, [Vol 31, Issue 1, (January 2011)] DOI: 10.1016/j.reprotox.2010.09.009. The original publication is available at www.elsevier.com.
URI: http://hdl.handle.net/10027/7781
ISSN: 0890-6238
Sponsor: Supported by NIH grant ES-015584 with supplemental NIH funding from American Recovery and Reinvestment Act.
Date Available in INDIGO: 2011-05-27
 

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