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Activation of the ERK1/2 Mitogen-Activated Protein Kinase Cascade by Dentin Matrix Protein 1 Promotes Osteoblast Differentiation

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Title: Activation of the ERK1/2 Mitogen-Activated Protein Kinase Cascade by Dentin Matrix Protein 1 Promotes Osteoblast Differentiation
Author(s): Eapen, Asha S.; Ramachandran, Amsaveni; Pratap, Jitesh; George, Anne
Subject(s): Dentin matrix protein 1 ERK1/2 MAP kinase
Abstract: DMP1 has been shown to play many roles in osteogenesis. We recently demonstrated that calcium-mediated stress kinase activation by DMP1 leads to osteoblast differentiation. In this study we demonstrate that DMP1 can also activate the extracellular signal-regulated kinase (ERK)-MAPK pathway. This activation was mediated through the RGD integrin-binding domain in DMP1. Further, we demonstrate that Runx2, an essential transcription factor, is stimulated by the ERK-MAPK pathway. Copyright © 2011 S. Karger AG, Basel
Issue Date: 2011-05-06
Publisher: Karger
Citation Info: Eapen, A., Ramachandran, A., Pratap, J., & George, A. 2011. Activation of the ERK1/2 Mitogen-Activated Protein Kinase Cascade by Dentin Matrix Protein 1 Promotes Osteoblast Differentiation. Cells Tissues Organs. DOI: 10.1159/000324258.
Type: Article
Description: Post print version of article may differ from published version. The definitive version is available through Karger at DOI: 10.1159/000324258 [http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000324258]. © 2011 S. Karger AG, Basel
URI: http://hdl.handle.net/10027/7818
ISSN: 1422-6405
Sponsor: This work was supported by National Institutes of Health Grant DE 11657 and by the Brodie Endowment Fund.
Date Available in INDIGO: 2011-06-01
 

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