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Comparison of Health-Related Quality of Life Measures in Chronic Obstructive Pulmonary Disease

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Title: Comparison of Health-Related Quality of Life Measures in Chronic Obstructive Pulmonary Disease
Author(s): Pickard, A. Simon; Yang, Yoojung; Lee, Todd A.
Subject(s): respiratory disease quality of life COPD health status EQ-5D
Abstract: Background: The aims of this study were: (1) to compare the discriminative ability of a disease-specific instrument, the St. George’s Respiratory Questionnaire (SGRQ) to generic instruments (i.e., EQ-5D and SF-36); and (2), to evaluate the strength of associations among clinical and health-related quality of life (HRQL) measures in chronic obstructive pulmonary disease (COPD). Methods: We analyzed data collected from 120 COPD patients in a Veterans Affairs hospital. Patients self-completed two generic HRQL measures (EQ-5D and SF-36) and the disease-specific SGRQ. The ability of the summary scores of these HRQL measures to discriminate COPD disease severity based on Global Obstructive Lung Disease (GOLD) stage was assessed using relative efficiency ratios (REs). Strength of correlation was used to further evaluate associations between clinical and HRQL measures. Results: Mean total scores for PCS-36, EQ-VAS and SGRQ were significantly lower for the more severe stages of COPD (p < 0.05). Using SGRQ total score as reference, the summary scores of the generic measures (PCS-36, MCS-36, EQ index, and EQ-VAS) all had REs of <1. SGRQ exhibited a stronger correlation with clinical measures than the generic summary scores. For instance, SGRQ was moderately correlated with FEV1 (r = 0.43), while generic summary scores had trivial levels of correlation with FEV1 (r < 0.2). Conclusions: The SGRQ demonstrated greater ability to discriminate among different levels of severity stages of COPD than generic measures of health, suggestive that SGRQ may provide COPD studies with greater statistical power than EQ-5D and SF-36 summary scores to capture meaningful differences in clinical severity.
Issue Date: 2011-04-18
Publisher: BioMed Central
Citation Info: Pickard, A. S., Yang, Y., & Lee, T. A. 2011. Comparison of health-related quality of life measures in chronic obstructive pulmonary disease. Health and Quality of Life Outcomes, 9(26). DOI: 10.1186/1477-7525-9-26
Type: Article
Description: © 2011 Pickard et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The original version is available through BioMed Central at DOI: 10.1186/1477-7525-9-26.
ISSN: 1477-7525
Date Available in INDIGO: 2012-03-06

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