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Carnosol: A Promising Anti-Cancer and Anti-Inflammatory Agent

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Title: Carnosol: A Promising Anti-Cancer and Anti-Inflammatory Agent
Author(s): Johnson, Jeremy J.
Subject(s): carnasol mediterranean diet
Abstract: The Mediterranean diet and more specifically certain meats, fruits, vegetables, and olive oil found in certain parts of the Mediterranean region have been associated with a decreased cardiovascular and diabetes risk. More recently, several population based studies have observed with these lifestyle choices have reported an overall reduced risk for several cancers. One study in particular observed an inverse relationship between consumption of Mediterranean herbs such as rosemary, sage, parsley, and oregano with lung cancer. In light of these findings there is a need to explore and identify the anti-cancer properties of these medicinal herbs and to identify the phytochemicals therein. One agent in particular, carnosol, has been evaluated for anti-cancer property in prostate, breast, skin, leukemia, and colon cancer with promising results. These studies have provided evidence that carnosol targets multiple deregulated pathways associated with inflammation and cancer that include nuclear factor kappa B (NFκB), apoptotic related proteins, phosphatidylinositol-3-kinase (PI3 K)/Akt, androgen and estrogen receptors, as well as molecular targets. In addition, carnosol appears to be well tolerated in that it has a selective toxicity towards cancer cells versus non-tumorigenic cells and is well tolerated when administered to animals. This mini-review reports on the pre-clinical studies that have been performed to date with carnosol describing mechanistic, efficacy, and safety/tolerability studies as a cancer chemoprevention and anti-cancer agent.
Issue Date: 2011-06-01
Publisher: Elsevier
Citation Info: Johnson, J. J. 2011. Carnosol: A Promising Anti-cancer and Anti-inflammatory Agent. Cancer Letters, 305(1): 1-7. DOI: 10.1016/j.canlet.2011.02.005
Type: Article
Description: NOTICE: this is the author’s version of a work that was accepted for publication in Cancer Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Cancer Letters, Vol 305, Issue 1, June 1, 2011. DOI: 10.1016/j.canlet.2011.02.005. The original publication is available at www.elsevier.com.
URI: http://hdl.handle.net/10027/8190
ISSN: 0304-3835
Sponsor: The original work that was performed with carnosol and prostate cancer was supported by NIH 1KL2RR025012 and K12 RR023268.
Date Available in INDIGO: 2012-03-09
 

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