INDIGO Home University of Illinois at Urbana-Champaign logo uic building uic pavilion uic student center

Structural and Functional Correlation in Sickle Cell Retinopathy Using Spectral-Domain Optical Coherence Tomography and Scanning Laser Ophthalmoscope Microperimetry

Show full item record

Bookmark or cite this item: http://hdl.handle.net/10027/8199

Files in this item

File Description Format
PDF chow.pdf (750KB) (no description provided) PDF
Title: Structural and Functional Correlation in Sickle Cell Retinopathy Using Spectral-Domain Optical Coherence Tomography and Scanning Laser Ophthalmoscope Microperimetry
Author(s): Chow, Clement C.; Genead, Mohamed A.; Anastasakis, Anastasios; Chau, Felix Y.; Fishman, Gerald A.; Lim, Jennifer I.
Abstract: Purpose: To correlate macular structural changes by spectral domain optical coherence tomography (SD-OCT) with functional changes by scanning laser ophthalmoscope (SLO) microperimetry testing in patients with sickle cell hemoglobinopathies. Design: Prospective, investigational study. Methods: Patients with electrophoretic confirmation of sickle cell hemoglobinopathies and normal subjects underwent SD-OCT and microperimetry testing with the OPKO Spectral OCT/SLO instrument. Based on SD-OCT findings, patients were grouped into those with focal macular thinning (Group A) and those without (Group B). Main outcome measure were mean retinal sensitivities measured by microperimetry and mean macular thicknesses in the 9 Early Treatment Diabetic Retinopathy Study (ETDRS)-like subfields. Results: Thirty-seven eyes of 19 patients with sickle cell hemoglobinopathies (SS, SC, and S-Thalassemia) and 34 eyes of 34 age similar normal controls were included. Mean age and mean logMAR best corrected visual acuity between Group A and B were not statistically different (39.7 years vs. 36.5 years, p = 0.64 and 0.015 vs. 0.016, p = 0.93, respectively). Group A had significantly thinner retinas compared to Group B in the parafoveal superior (p = 0.019), parafoveal temporal (p < 0.004), parafoveal inferior (p = 0.003), perifoveal superior (p = 0.04), perifoveal temporal (p = 0.0005), and perifoveal inferior (p = 0.045) subfields. The overall mean microperimetry retinal sensitivities of Group A were significantly less than those of Group B (14.2 dB vs. 16.5 dB, p = 0.00005). However, there was no statistical difference between Group B and controls (16.5 dB vs. 16.7 dB, p = 0.63). Conclusion: Sickle cell patients with focal macular thinning present on SD-OCT have significantly decreased retinal sensitivities compared to those without focal thinning or normal controls based on mean microperimetry sensitivities, despite similar age and visual acuity. Microperimetry is a sensitive measurement of macular function in patients with sickle cell hemoglobinopathies.
Issue Date: 2011-07-02
Publisher: Elsevier Masson
Citation Info: Chow, C. C., Genead, M. A., Anastasakis, A., Chau, F. Y., Fishman, G. A., & Lim, J. I. Structural and Functional Correlation in Sickle Cell Retinopathy Using Spectral-Domain Optical Coherence Tomography and Scanning Laser Ophthalmoscope Microperimetry. American Journal of Ophthalmology . 152 (4): 704-711.e2. 2011. DOI: 10.1016/j.ajo.2011.03.035
Type: Article
Description: NOTICE: this is the author’s version of a work that was accepted for publication in the American Journal of Ophthalmology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in the American Journal of Ophthalmology, Vol.152, Issue 4 (July 2, 2011). DOI: 10.1016/j.ajo.2011.03.035. The original publication is available at www.elsevier.com.
URI: http://hdl.handle.net/10027/8199
ISSN: 0002-9394
Sponsor: This study was supported by the Foundation Fighting Blindness, Owing Mills, Maryland, and Grant Healthcare Foundation, Chicago, Illinois (GF); NIH core grant EY01792; Gerhard Cless Retina Research Fund (JL); University of Illinois Core Grant EY495707, and an unrestricted grant from Research to Prevent Blindness, New York, New York.
Date Available in INDIGO: 2012-03-15
 

This item appears in the following Collection(s)

Show full item record

Statistics

Country Code Views
United States of America 111
China 50
United Kingdom 2
Australia 1
Bermuda 1

Browse

My Account

Information

Access Key