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Anatomical Correlates of Age Related Working Memory Declines

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Title: Anatomical Correlates of Age Related Working Memory Declines
Author(s): Schulze, Evan T.; Geary, Elizabeth K.; Susmaras, Teresa M.; Paliga, James T.; Maki, Pauline M.; Little, Deborah M.
Abstract: Aging studies consistently show a relationship between decreased gray matter volume and decreased performance on working memory tasks. Few aging studies have investigated white matter changes in relation to functional brain changes during working memory tasks. Twenty-five younger and 25 older adults underwent anatomical magnetic resonance imaging (MRI) scans to measure gray matter volume, diffusion tensor imaging (DTI) to measure fractional anisotropy (FA) as a measure of white matter integrity, and functional magnetic resonance imaging (fMRI) while performing a working memory task. Significant increases in activation (fMRI) were seen in the left dorsal and ventral lateral prefrontal cortex with increased working memory load and with increased age (older showing greater bilateral activation). Partial correlational analyses revealed that even after controlling for age, frontal FA correlated significantly with fMRI activation during performance on the working memory task. These findings highlight the importance of white matter integrity in working memory performance associated with normal aging.
Issue Date: 2011-08
Publisher: SAGE-Hindawi Access to Research
Citation Info: Schulze, E. T., Geary, E. K., Susmaras, T. M., Paliga, J. T., Maki, P. M., & Little, D. M. 2011. Anatomical correlates of age-related working memory declines. Journal of Aging Research, 2011: 606871. doi:10.4061/2011/606871
Type: Article
Description: Copyright © 2011 Evan T. Schulze et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. doi:10.4061/2011/606871
URI: http://hdl.handle.net/10027/8224
ISSN: 2090-2204
Sponsor: This work was supported by NIH Grant no. R21 AG028662 (PI: D. M. Little) from the National Institute on Aging, the University of Illinois College of Medicine (D. M. Little), and the Kravis Leadership Institute at Claremont McKenna College (J. T. Paliga). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Institute of Aging, Department of Veterans Affairs, United States Government, University of Illinois at Chicago, Texas A&M, or Duke University.
Date Available in INDIGO: 2012-03-16
 

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