INDIGO Home University of Illinois at Urbana-Champaign logo uic building uic pavilion uic student center

Modulation of Ischemia-Induced NMDAR1 Activation by Environmental Enrichment Decreases Oxidative Damage

Show full item record

Bookmark or cite this item: http://hdl.handle.net/10027/8297

Files in this item

File Description Format
PDF npsBC7E.pdf (211KB) (no description provided) PDF
Title: Modulation of Ischemia-Induced NMDAR1 Activation by Environmental Enrichment Decreases Oxidative Damage
Author(s): Briones, Teresita L.; Rogozinska, Magdalena; Woods, Julie
Abstract: In this study, we examined whether enriched environment (EE) housing has direct neuroprotective effects on oxidative damage following transient global cerebral ischemia. Fifty-two adult maleWistar rats were included in the study and received either ischemia or sham surgery. Once fully awake, rats in each group were randomly assigned to either: EE housing or socially paired housing (CON). Animals remained in their assigned environment for 7 days, and then were killed. Our data showed that glutamate receptor expression was significantly higher in the hippocampus of the ischemia CON group than in the ischemia EE group. Furthermore, the oxidative DNA damage, protein oxidation, and neurodegeneration in the hippocampus of the ischemia CON group were significantly increased compared to the ischemia EE group. These results suggest that EE housing possibly modulated the ischemia-induced glutamate excitotoxicity, which then attenuated the oxidative damage and neurodegeneration in the ischemia EE rats.
Issue Date: 2011-12
Publisher: Mary Ann Liebert
Citation Info: Briones, T. L., Rogozinska, M., & Woods, J. 2011. Modulation of Ischemia-Induced NMDAR1 Activation by Environmental Enrichment Decreases Oxidative Damage. Journal of Neurotrauma, 28(12): 2485-2492. DOI: 10.1089/neu.2011.1842
Type: Article
Description: This is a copy of an article published in the Journal of Neurotrauma © 2011 copyright Mary Ann Liebert, Inc; Journal of Neurotrauma is available online at: http://www.liebertonline.com. DOI: 10.1089/neu.2011.1842
URI: http://hdl.handle.net/10027/8297
ISSN: 0897-7151
Sponsor: This work was supported by the National Institutes of Health, NINR grant # RO1 NR007666.
Date Available in INDIGO: 2012-04-30
 

This item appears in the following Collection(s)

Show full item record

Statistics

Country Code Views
United States of America 158
China 19
United Kingdom 15
Germany 5
Netherlands 2

Browse

My Account

Information

Access Key