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Fractional Order Analysis of Sephadex Gel Structures: NMR Measurements Reflecting Anomalous Diffusion

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Title: Fractional Order Analysis of Sephadex Gel Structures: NMR Measurements Reflecting Anomalous Diffusion
Author(s): Magin, Richard L.; Akpa, Belinda S.; Neuberger, Thomas; Webb, Andrew G.
Subject(s): diffusion exponential fractional derivative fractal magnetic resonance Sephadex gel
Abstract: We report the appearance of anomalous water diffusion in hydrophilic Sephadex gels observed using pulse field gradient (PFG) nuclear magnetic resonance (NMR). The NMR diffusion data was collected using a Varian 14.1 Tesla imaging system with a home-built RF saddle coil. A fractional order analysis of the data was used to characterize heterogeneity in the gels for the dynamics of water diffusion in this restricted environment. Several recent studies of anomalous diffusion have used the stretched exponential function to model the decay of the NMR signal, i.e., exp[-(bD)α], where D is the apparent diffusion constant, b is determined the experimental conditions (gradient pulse separation, durations and strength), and α is a measure of structural complexity. In this work, we consider a different case where the spatial Laplacian in the Bloch-Torrey equation is generalized to a fractional order model of diffusivity via a complexity parameter, β, a space constant, μ, and a diffusion coefficient, D. This treatment reverts to the classical result for the integer order case. The fractional order decay model was fit to the diffusion-weighted signal attenuation for a range of b-values (0 < b < 4,000 s-mm-2). Throughout this range of b values, the parameters β, μ and D, were found to correlate with the porosity and tortuosity of the gel structure.
Issue Date: 2011-12-01
Publisher: Elsevier
Citation Info: Magin, R. L., Akpa, B. S., Neuberger, T., & Webb, A. G. 2011. Fractional order analysis of Sephadex gel structures: NMR measurements reflecting anomalous diffusion. Communications in Nonlinear Science and Numerical Simulation, 16(12): 4581-4587. DOI: 10.1016/j.cnsns.2011.04.002
Type: Article
Description: NOTICE: this is the author’s version of a work that was accepted for publication in Communications in Nonlinear Science and Numerical Simulation . Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Communications in Nonlinear Science and Numerical Simulation , [Vol 16, Issue 12, (December 2011)] DOI: 10.1016/j.cnsns.2011.04.002. The original publication is available at
ISSN: 1007-5704
Sponsor: R. L. Magin would like to acknowledge the support of NIH grant R01 EB007537 for partial support of this work.
Date Available in INDIGO: 2012-06-25

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