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Metabolic Stress, Reactive Oxygen Species, and Arrhythmia

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Title: Metabolic Stress, Reactive Oxygen Species, and Arrhythmia
Author(s): Jeong, Euy-Myoung; Liu, Man; Sturdy, Megan; Gao, Ge; Sovari, Ali A.; Dudley, Samuel C.
Subject(s): reactive oxygen species sodium channel arrhythmia connexin mitochondria
Abstract: Cardiac arrhythmias can cause sudden cardiac death (SCD) and add to the current heart failure (HF) health crisis. Nevertheless, the pathological processes underlying arrhythmias are unclear. Arrhythmic conditions are associated with systemic and cardiac oxidative stress caused by reactive oxygen species (ROS). In excitable cardiac cells, ROS regulate both cellular metabolism and ion homeostasis. Increasing evidence suggests that elevated cellular ROS can cause alterations of the cardiac sodium channel (Na(v)1.5), abnormal Ca2+ handling, changes of mitochondrial function, and gap junction remodeling, leading to arrhythmogenesis. This review summarizes our knowledge of the mechanisms by which ROS may cause arrhythmias and discusses potential therapeutic strategies to prevent arrhythmias by targeting ROS and its consequences.
Issue Date: 2012-02
Publisher: Elsevier
Citation Info: Jeong, E. M., Liu, M., Sturdy, M., Gao, G., Varghese, S. T., Sovari, A. A., & Dudley, S. C. 2012. Metabolic stress, reactive oxygen species, and arrhythmia. Journal of Molecular and Cellular Cardiology, 52(2): 454-463. DOI: 10.1016/j.yjmcc.2011.09.018
Type: Article
Description: NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Molecular and Cellular Cardiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Molecular and Cellular Cardiology Volume 52, Issue 2, Feb 2012. DOI: 10.1016/j.yjmcc.2011.09.018
URI: http://hdl.handle.net/10027/8397
ISSN: 0022-2828
Date Available in INDIGO: 2012-06-27
 

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