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Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vitro and In Vivo

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Title: Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vitro and In Vivo
Author(s): Yang, Zhonghan; Grinchuk, Viktoriya; Ip, Siu Po; Che, Chun-Tao; Fong, Harry H. S.; Lao, Lixing; Wu, Justin C.; Sung, Joseph J.; Berman, Brian; Shea-Donohue, Terez; Zhao, Aiping
Abstract: Irritable bowel syndrome (IBS) is a unctional bowel disorder and the etiology is not well understood. Currently there is no cure for IBS and no existing medication induces symptom relief in all patients. IBS-20 is a 20-herb Chinese medicinal formula that offers beneficial effects in patients with IBS; however, the underlying mechanisms are largely unknown. This study showed that IBS-20 potently inhibited LPS- or IFNΓ-stimulated expression of pro-inflammatory cytokines, as well as classically activated macrophage marker nitric oxide synthase 2. Similarly, IBS-20 or the component herb Coptis chinensis decreased LPS-stimulated pro-inflammatory cytokine secretion from JAWS II dendritic cells. IBS-20 or the component herbs also blocked or attenuated the IFNΓ-induced drop in transepithelial electric resistance, an index of permeability, in fully differentiated Caco-2 monolayer. Finally, the up-regulation of key inflammatory cytokines in inflamed colon from TNBS-treated mice was suppressed significantly by orally administrated IBS-20, including IFNΓ and IL-12p40. These data indicate that the anti-inflammatory activities of IBS-20 may contribute to the beneficial effects of the herbal extract in patients with IBS, providing a potential mechanism of action for IBS-20. In addition, IBS-20may be a potential therapeutic agent against other Th1-dominant gut pathologies such as inflammatory bowel disease.
Issue Date: 2012
Publisher: Hindawi Publishing Corporation
Citation Info: Yang, Z. H., Grinchuk, V., Ip, S. P., Che, C. T., Fong, H. H. S., Lao, L. X., Wu, J. C., Sung, J. J., Berman, B., Shea-Donohue, T., & Zhao, A. P. 2012. Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. DOI: 10.1155/2012/491496
Type: Article
Description: Copyright © 2012 Zhonghan Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: 10.1155/2012/491496
URI: http://hdl.handle.net/10027/8416
ISSN: 1741-427X
Sponsor: This work was supported by the Pilot Project from NICCM 1U19 AT003266-04.
Date Available in INDIGO: 2012-07-24
 

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