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Associations between functional polymorphisms in antioxidant defense genes and urinary oxidative stress biomarkers in healthy, premenoupausal women

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Title: Associations between functional polymorphisms in antioxidant defense genes and urinary oxidative stress biomarkers in healthy, premenoupausal women
Author(s): Al-Alem, Umaima; Gann, Peter H.; Dahl, Jeffrey; Breemen, Richard B. van; Mistry, Vilas; Lam, Patricia M.W.; Evans, Mark D.; Horn, Linda Van; Wright, Margaret E.
Abstract: Functional polymorphisms in endogenous antioxidant defense genes including manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase (GPX-1) have been linked with risk of cancer at multiple sites. Although it is presumed that these germline variants impact disease risk by altering the host’s ability to detoxify mutagenic reactive oxygen species, very few studies have directly examined this hypothesis. Concentrations of 8-isoprostane F2α (8-iso-PGF2α) and 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxoxdG) – sensitive indicators of lipid peroxidation and DNA oxidation, respectively – were measured in 24-hour urine samples obtained from 93 healthy, premenopausal women participating in a dietary intervention trial. In addition, DNA was extracted from blood for genotyping of MnSOD Val16Ala, CAT -262 C>T, and GPX1 Pro198Leu genotypes by Taqman assay. Although geometric mean concentrations of 8-iso-PGF2α and 8-oxoxdG varied across several study characteristics including race, education level, body mass index, and serum antioxidant levels, there was little evidence that these biomarkers differed across any of the examined genotypes. In summary, functional polymorphisms in endogenous antioxidant defense genes do not appear to be strongly associated with systemic oxidative stress levels in young, healthy women.
Issue Date: 2012
Publisher: Springer Verlag
Citation Info: Al-Alem, U., Gann, P. H., Dahl, J., van Breemen, R. B., Mistry, V., Lam, P. M., Evans, M. D., Van, H. L., & Wright, M. E. 2011. Associations between functional polymorphisms in antioxidant defense genes and urinary oxidative stress biomarkers in healthy, premenopausal women. Genes and Nutrition. Apr;7(2):191-5. DOI: 10.1007/s12263-011-0257-3
Type: Article
Description: © 2012 by Springer Verlag, Genes and Nutrition The original publication is available at www.springerlink.com DOI: 10.1007/s12263-011-0257-3
URI: http://hdl.handle.net/10027/8449
ISSN: 1555-8932
Sponsor: Funding was provided by a pilot grant from the University of Illinois at Chicago Cancer Center.
Date Available in INDIGO: 2012-08-14
 

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