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Byrsonima fagifolia Niedenzu Apolar Compounds with Antitubercular Activity

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Title: Byrsonima fagifolia Niedenzu Apolar Compounds with Antitubercular Activity
Author(s): Higuchi, C.; Sannomiya, M.; Pavan, F.; Leite, S.; Sato, D.; Franzblau, S.; Sacramento, L.V.; Vilegas, W.; Leite, C.
Abstract: Bioassay-guided fractionation of the chloroform extract of Byrsonima fagifolia leaves led to the isolation of active antitubercular compounds alkane dotriacontane (Minimal Inhibitory Concentration-MIC, 62.5 mu g mL(-1)), triterpenoids as bassic acid (MIC = 2.5 mu g mL(-1)), alpha-amyrin acetate (MIC = 62.5 mu g mL(-1)), a mixture of lupeol, alpha- and beta-amyrin (MIC = 31.5 mu g mL(-1)) and a mixture of lupeol, and acetates of alpha- and beta-amyrin (MIC = 31.5 mu g mL(-1)). The antimycobacterial activity was determined by the Microplate Alamar Blue Assay (MABA) and the structures of promising compounds were determined by spectroscopic analysis. This investigation constitutes the first report of a chemical and antitubercular study of apolar compounds from B. fagifolia Niedenzu (IK).
Issue Date: 2011
Publisher: Hindawi Publishing Corporation
Citation Info: Higuchi, C., Sannomiya, M., Pavan, F., Leite, S., Sato, D., Franzblau, S., Sacramento, L., V, Vilegas, W., & Leite, C. 2011. Byrsonima fagifolia Niedenzu Apolar Compounds with Antitubercular Activity. Evidence-Based Complementary and Alternative Medicine. Volume 2011, Article ID 128349. DOI: 10.1093/ecam/nen077
Type: Article
Description: Copyright © 2011 C. T. Higuchi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: 10.1093/ecam/nen077
URI: http://hdl.handle.net/10027/8485
ISSN: 1741-427X
Sponsor: The authors thank the Fundac¸˜ao de Amparo `a Pesquisa do Estado de S˜ao Paulo (FAPESP) for a grant to Miriam Sannomiya and Fernando Rog´erio Pavan, and for funding of the project Biota-Fapesp 02/05503-6. They also thank CNPq for a grant to W. Vilegas.
Date Available in INDIGO: 2012-08-16
 

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