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Ocular and Oral Mucous Membrane Pemphigoid (Cicatricial Pemphigoid)

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Title: Ocular and Oral Mucous Membrane Pemphigoid (Cicatricial Pemphigoid)
Author(s): Chan, Lawrence S.
Abstract: Mucous membrane pemphigoid, a heterogeneous group of autoimmune blistering diseases, affect primarily the mucous membranes. While both oral and ocular mucosae can be affected in a given patient, patients have involvement restricted to oral mucosae tend to have a benign outcome, whereas those with ocular disease commonly face treatment resistance and result in scarring and blindness. Diagnosis requires a direct immunofluorescence microscopy demonstrating a linear deposition of IgG, IgA, or C3 at the epithelial basement membrane. While the target antigens vary, subsets of patients affected exclusively by oral and ocular mucosal diseases have autoantibodies targeting alpha‐6 and beta‐4 integrins, respectively.
Issue Date: 2012
Publisher: Elsevier
Citation Info: Chan, L. S. 2012. Ocular and oral mucous membrane pemphigoid (cicatricial pemphigoid). Clinics in Dermatology, 30(1): 34-37. DOI: 10.1016/j.clindermatol.2011.03.007
Type: Article
Description: NOTICE: this is the author’s version of a work that was accepted for publication in Clinics in Dermatology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Clinics in Dermatology, Vol 30, Issue 1, Jan/Feb 2012. DOI: 10.1016/j.clindermatol.2011.03.007
URI: http://hdl.handle.net/10027/8518
ISSN: 0738-081X
Date Available in INDIGO: 2012-08-17
 

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