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Engineering Periplasmic Ligand Binding Proteins as Glucose Nanosensors

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Title: Engineering Periplasmic Ligand Binding Proteins as Glucose Nanosensors
Author(s): Jeffery, Constance J.
Abstract: Diabetes affects over 100 million people worldwide. Better methods for monitoring blood glucose levels are needed for improving disease management. Several labs have previously made glucose nanosensors by modifying members of the periplasmic ligand binding protein superfamily. This minireview summarizes recent developments in constructing new versions of these proteins that are responsive within the physiological range of blood glucose levels, employ new reporter groups, and/or are more robust. These experiments are important steps in the development of novel proteins that have the characteristics needed for an implantable glucose nanosensor for diabetes management: specificity for glucose, rapid response, sensitivity within the physiological range of glucose concentrations, reproducibility, and robustness.
Issue Date: 2011
Publisher: Co-Action Publishing
Citation Info: Jeffery, C. J. 2011. Engineering periplasmic ligand binding proteins as glucose nanosensors. Nano Reviews, 2: 5743. doi 10.3402/nano.v2i0.5743
Type: Article
Description: This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. doi 10.3402/nano.v2i0.5743
URI: http://hdl.handle.net/10027/8529
ISSN: 2000-5121
Date Available in INDIGO: 2012-08-17
 

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