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Questionable Effectiveness of the QuantiFERON-TB Gold Test (Cellestis) as a Screening Tool in Healthcare Workers

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Title: Questionable Effectiveness of the QuantiFERON-TB Gold Test (Cellestis) as a Screening Tool in Healthcare Workers
Author(s): Gandra, Sumanth; Scott, William S.; Somaraju, Vijaya; Wang, Huaping; Wilton, Suzanne; Feigenbaum, Michelle
Abstract: objective. The Center for Disease Control and Prevention recommends the use of QuantiFERON TB Gold test (QFTG; Cellestis) in all situations where the tuberculin skin test (TST) is used. In November 2007, our institution replaced its screening-tool TST with the QFTG in-tube assay (QFT-GIT) for annual screening of latent tuberculosis infection among healthcare workers (HCWs). This study evaluated the effectiveness of QFT-GIT test as screening tool in HCWs at our institution. methods. This retrospective study reviewed medical records of all HCWs who underwent screening with QFT-GIT from January 2008 through December 2008. results. Among the 6,530 HCWs screened with QFT-GIT from January through December 2008, 287 had a positive test result. Of the 287, 123 had positive TST results in the past, meaning that 164 HCWs had newly diagnosed latent tuberculosis infection by QFT-GIT. Of the 164 HCWs, 135 were retested by QFT-GIT and were simultaneously tested with TST within 4 weeks after the initial QFT-GIT. Of these 135 HCWs, 66 reverted to negative results and results remained positive for 69 with QFT-GIT. Only 2 HCWs had a positive TST result. conclusions. The disagreement between QFT-GIT and TST results and the high reversion rate with QFT-GIT raise concerns about the effectiveness of QFT-GIT as a sole screening test in HCWs.
Issue Date: 2010-12
Publisher: Endocrine Society
Citation Info: Gandra, S., Scott, W. S., Somaraju, V., Wang, H., Wilton, S., & Feigenbaum, M. 2010. Questionable effectiveness of the QuantiFERON-TB Gold Test (Cellestis) as a screening tool in healthcare workers. Journal of Clinical Endocrinology and Metabolism, 31(12): 1279-1285. DOI: 10.1086/657336
Type: Article
Description: © 2011 by Endocrine Society, Journal of Clinical Endocrinology and Metabolism DOI: 10.1086/657336
ISSN: 0021-972X
Date Available in INDIGO: 2012-08-17

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