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Combined treatment of Aβ immunization with statin in a mouse model of Alzheimer's disease

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Title: Combined treatment of Aβ immunization with statin in a mouse model of Alzheimer's disease
Author(s): Kou, Jinghong; Song, Min; Pattanayak, Abhinandan; Lim, Jeong-Eun; Yang, Junling; Cao, Dongfeng; Li, Ling; Fukuchi, Ken-ichiro
Abstract: We evaluated the therapeutic efficacy of combined treatment of Aβ-immunization with simvastatin in an Alzheimer mouse model at age 22 months. DNA prime-adenovirus boost immunization induced modest anti-Aβ titers and simvastatin increased the seropositive rate. Aβ-KLH was additionally administered to boost the titers. Irrespective of simvastatin, the immunization did not decrease cerebral Aβ deposits but increased soluble Aβ and tended to exacerbate amyloid angiopathy in the hippocampus. The immunization increased cerebral invasion of leukocytes and simvastatin counteracted the increase. Thus, modest anti-Aβ titers can increase soluble Aβ and simvastatin may reduce inflammation associated with vaccination in aged Alzheimer mouse models.
Issue Date: 2012-03
Publisher: Elsevier
Citation Info: Kou, J., Song, M., Pattanayak, A., Lim, J. E., Yang, J., Cao, D., Li, L., & Fukuchi, K. I. 2012. Combined treatment of Abeta immunization with statin in a mouse model of Alzheimer's disease. Journal of Neuroimmunology, 244(1–2):70–83. doi.org/10.1016/j.jneuroim.2012.01.008
Type: Article
Description: NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Neuroimmunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Neuroimmunology, [Vol 244, Issue 1-2, (March 2012)] DOI: doi.org/10.1016/j.jneuroim.2012.01.008
URI: http://hdl.handle.net/10027/8541
ISSN: 0165-5728
Sponsor: This research was supported in part by grants from the National Institutes of Health (AG031846, AG031979, AG037814, AG030399, AG029818 and EY018478) and the Alzheimer’s Association (IIRG-07-59494).
Date Available in INDIGO: 2012-08-17
 

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