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Structural and Functional Characteristics in Carriers of X-Linked Retinitis Pigmentosa with a Tapetal-Like Reflex

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Title: Structural and Functional Characteristics in Carriers of X-Linked Retinitis Pigmentosa with a Tapetal-Like Reflex
Author(s): Genead, Mohamed A.; Fishman, Gerald A.; Lindeman, Martin
Abstract: Purpose: to identify the functional and structural characteristics in three female obligate carriers of X-linked retinitis pigmentosa (XLRP) from the same family by using spectraldomain OCT (SD-OCT), fundus autofluorescence (FAF), and microperimetry (MP). Methods: Three female obligate carriers with a tapetal-like reflex (TLR), 21, 49, and 57 years of age, from a single family of XLRP that was seen in the ophthalmology department at the University of Illinois at Chicago, were enrolled in the study. All carriers underwent a complete ophthalmic examination. SD-OCT measurements, a macular MP exam, and FAF testing were performed. Results: The SD-OCT exam in all three carriers showed a normal retinal micro-structure and thickness. Microperimeter testing showed subnormal retinal sensitivity in the areas of the TLR. FAF exam showed the presence of speckled areas of enhanced AF. Conclusions: Our study demonstrates that the carriers of XLRP with a TLR can show an enhanced reflectance on infrared images, abnormal autofluorescence properties, elevated retinal thresholds, and a normal retinal morphology within the posterior pole on SD-OCT testing
Issue Date: 2010
Publisher: Lippincott, Williams & Wilkins
Citation Info: Genead, M. A., Fishman, G. A., & Lindeman, M. 2010. Structural and Functional Characteristics in Carriers of X-Linked Retinitis Pigmentosa with a Tapetal-Like Reflex. Retina. 30(10): 1726-1733. DOI: 10.1097/IAE.0b013e3181dde629
Type: Article
Description: Post print version of article may differ from published version. The definitive version is available through Lippincott, Williams & Wilkins at DOI: 10.1097/IAE.0b013e3181dde629
URI: http://hdl.handle.net/10027/8585
ISSN: 1539-2864
Sponsor: Supported by funds from the Foundation Fighting Blindness, Owings Mills, Maryland; Grant Healthcare Foundation, Lake Forest, Illinois; NIH core grant EYO1792; and an unrestricted departmental grant from Research to Prevent Blindness.
Date Available in INDIGO: 2012-08-20
 

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