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Anti-Melanogenic Property of Geoditin A in Murine B16 Melanoma Cells

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Title: Anti-Melanogenic Property of Geoditin A in Murine B16 Melanoma Cells
Author(s): Cheung, Florence W. K.; Guo, Jia; Ling, Yick-Hin; Che, Chun-Tao; Liu, Wing-Keung
Subject(s): geoditin A B16 melanoma cells melanogenesis tyrosinase
Abstract: Geoditin A, an isomalabaricane triterpene isolated from marine sponge Geodia japonica, has been demonstrated to induce apoptosis in leukemia HL60 cells and human colon HT29 cancer cells through an oxidative stress, a process also interfering with normal melanogenesis in pigment cells. Treatment of murine melanoma B16 cells with geoditin A decreased expression of melanogenic proteins and cell melanogenesis which was aggravated with adenylate cyclase inhibitor SQ22536, indicating melanogenic inhibition was mediated through a cAMP-dependent signaling pathway. Immunofluorescence microscopy and glycosylation studies revealed abnormal glycosylation patterns of melanogenic proteins (tyrosinase and tyrosinase-related protein 1), and a co-localization of tyrosinase with calnexin (CNX) and lysosome-associated membrane protein 1 (LAMP-1), implicating a post-translational modification in the ER and a degradation of tyrosinase in the lysosome. Taken together, potent anti-melanogenic property and the relatively low cytotoxicity of geoditin A have demonstrated its therapeutic potential as a skin lightening agent.
Issue Date: 2012-02
Publisher: MDPI
Citation Info: Cheung, F. W. K., J. Guo, et al. (2012). "Anti-Melanogenic Property of Geoditin A in Murine B16 Melanoma Cells." Marine Drugs 10(2): 465-476. DOI: 10.3390/md10020465
Type: Article
Description: The original version is available through Marine Drugs at DOI:10.3390/md10020465 © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
URI: http://hdl.handle.net/10027/8667
ISSN: 1660-3397
Date Available in INDIGO: 2012-09-10
 

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