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PKCα and ERβ Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients

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Title: PKCα and ERβ Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients
Author(s): Tonetti, Debra A.; Gao, Weihua; Escarzaga, Diana; Walters, Kelly; Szafran, April; Coon, John S.
Abstract: Although the incidence of breast cancer in the United States is higher in Caucasian women compared with African American women, African-American patients have more aggressive disease as characterized by a higher percentage of triple-negative breast cancers (TNBCs), high-grade tumors, and a higher mortality rate. PKCα is a biomarker associated with endocrine resistance and poor prognosis and ERβ is emerging as a protective biomarker. Immunohistochemical analysis of ERβ and PKCα expression was performed on 198 formalin-fixed paraffin-embedded primary infiltrating ductal carcinomas from 105 African-American and 93 Caucasian patients. PKCα is positively correlated with TNBC in patients of both races and with high tumor grade in African- American patients. Patients with TNBC express less nuclear ERβ compared with all other subtypes. We find no difference in frequency or intensity of PKCα or ERβ expression between African-American and Caucasian patients. PKCα and ERβ are discussed as potential therapeutic targets for the treatment of patients with TNBC.
Issue Date: 2012
Publisher: SAGE-Hindawi Access to Research
Citation Info: Tonetti DA, Gao W, Escarzaga D, Walters K, Szafran A, Coon JS. PKCα and ERβ Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients. International Journal of Breast Cancer. 2012;2012:740353. DOI: 10.1155/2012/740353
Type: Article
Description: Copyright © 2012 Debra A. Tonetti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: 10.1155/2012/740353
URI: http://hdl.handle.net/10027/8718
ISSN: 2090-3189
Date Available in INDIGO: 2012-10-02
 

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