INDIGO Home University of Illinois at Urbana-Champaign logo uic building uic pavilion uic student center

NMR Studies of Viral Envelope Proteins

Show full item record

Bookmark or cite this item:

Files in this item

File Description Format
PDF Celigoy_Jessica.pdf (8MB) (no description provided) PDF
Title: NMR Studies of Viral Envelope Proteins
Author(s): Celigoy, Jessica G.
Advisor(s): Caffrey, Michael
Contributor(s): Gaponenko, Vadim; Johnson, Michael; Kaplan, Jack; Rong, Lijun
Department / Program: Biochemistry and Molecular Genetics
Graduate Major: Biochemistry and Molecular Genetics
Degree Granting Institution: University of Illinois at Chicago
Degree: PhD, Doctor of Philosophy
Genre: Doctoral
Subject(s): NMR envelope proteins HIV-1 SARS-CoV
Abstract: Detailed structural information about viral envelope proteins is necessary for a better understanding of the viral entry mechanism, as well as for the development of new and improved anti-viral therapies, especially those targeting the pre-fusion and intermediate states of these conformations. The work presented here focuses on using various biochemical and NMR techniques to gather more information on the structure of the envelope proteins of SARS-CoV and HIV-1. Using these techniques I identified an intermediate state of S2-HR2 in the entry of SARS-CoV, which led to a more detailed proposed mechanism along with characterization of the prefusion state of S2-HR2. For the HIV-1 work I was able to use a peptide probe previously described to bind to HIV-1, 12p1, to probe the gp120/gp41 interface and gather details on the conformational changes that occur in this particular region during viral entry.
Issue Date: 2012-12-07
Genre: thesis
Rights Information: Copyright 2011 Jessica G. Celigoy
Date Available in INDIGO: 2012-12-07
Date Deposited: 2011-12

This item appears in the following Collection(s)

Show full item record


Country Code Views
United States of America 87
China 25
United Kingdom 14
France 2
Netherlands 2


My Account


Access Key