10027/10499
Mary E. Mackesy-Amiti
Mary E.
Mackesy-Amiti
Lorna Finnegan
Lorna
Finnegan
Lawrence J. Ouellet
Lawrence J.
Ouellet
Elizabeth T. Golub
Elizabeth T.
Golub
Holly Hagan
Holly
Hagan
Sharon M. Hudson
Sharon M.
Hudson
Mary H. Latka
Mary H.
Latka
Richard S. Garfein
Richard S.
Garfein
Peer-education Intervention to Reduce Injection Risk Behaviors Benefits High-Risk Young Injection Drug Users: A Latent Transition Analysis of the CIDUS 3/DUIT Study
University of Illinois at Chicago
2013
injection drug use
intervention
HIV
HCV
latent class analysis
2013-11-15 00:00:00
Journal contribution
https://indigo.uic.edu/articles/journal_contribution/Peer-education_Intervention_to_Reduce_Injection_Risk_Behaviors_Benefits_High-Risk_Young_Injection_Drug_Users_A_Latent_Transition_Analysis_of_the_CIDUS_3_DUIT_Study/10755377
We analyzed data from a large randomized HIV/HCV prevention intervention trial with young injection drug users (IDUs) conducted in five U.S. cities. The trial compared a peer education intervention (PEI) with a time-matched, attention control group. Applying categorical latent variable analysis (mixture modeling) to baseline injection risk behavior data, we identified four distinct classes of injection-related HIV/HCV risk: low risk, non-syringe equipment-sharing, moderate-risk syringe-sharing, and high-risk syringe-sharing. The trial participation rate did not vary across classes. We conducted a latent transition analysis using trial baseline and 6-month follow-up data, to test the effect of the intervention on transitions to the low-risk class at follow-up. Adjusting for gender, age, and race/ethnicity, a significant intervention effect was found only for the high-risk class. Young IDU who exhibited high-risk behavior at baseline were 90% more likely to be in the low-risk class at follow-up after the PEI intervention, compared to the control group.