10027/7621
Marnita L. Benford
Marnita L.
Benford
Tiva T. VanCleave
Tiva T.
VanCleave
Nicole A. Lavender
Nicole A.
Lavender
Rick A. Kittles
Rick A.
Kittles
LaCreis R. Kidd
LaCreis R.
Kidd
8q24 sequence variants in relation to prostate cancer risk among men of African descent: A case-control study
University of Illinois at Chicago
2011
chromosome 8Q24
prostate cancer
2011-05-12 00:00:00
Journal contribution
https://indigo.uic.edu/articles/journal_contribution/8q24_sequence_variants_in_relation_to_prostate_cancer_risk_among_men_of_African_descent_A_case-control_study/10759301
Background: Human chromosome 8q24 has been implicated in prostate tumorigenesis.
Methods: Consequently, we evaluated seven 8q24 sequence variants relative to prostate cancer (PCA) in a case-control study involving men of African descent. Genetic alterations were detected in germ-line DNA from 195 incident PCA cases and 531 controls using TaqMan polymerase chain reaction (PCR).
Results: Inheritance of the 8q24 rs16901979 T allele corresponded to a 2.5-fold increase in the risk of developing PCA for our test group. These findings were validated using multifactor dimensionality reduction (MDR) and permutation testing (p = 0.038). The remaining 8q24 targets were not significantly related to PCA outcomes.
Conclusions: Although compelling evidence suggests that the 8q24 rs16901979 locus may serve as an effective PCA predictor, our findings require additional evaluation in larger studies.