Activation of the ERK1/2 Mitogen-Activated Protein Kinase Cascade by Dentin Matrix Protein 1 Promotes Osteoblast Differentiation
Asha S. Eapen
Amsaveni Ramachandran
Jitesh Pratap
Anne George
10027/7818
https://indigo.uic.edu/articles/journal_contribution/Activation_of_the_ERK1_2_Mitogen-Activated_Protein_Kinase_Cascade_by_Dentin_Matrix_Protein_1_Promotes_Osteoblast_Differentiation/10763309
DMP1 has been shown to play many roles in osteogenesis. We recently demonstrated that calcium-mediated stress kinase activation by DMP1 leads to osteoblast differentiation. In this study we demonstrate that DMP1 can also activate the extracellular signal-regulated kinase (ERK)-MAPK pathway. This activation was mediated through the RGD integrin-binding domain in DMP1. Further, we demonstrate that Runx2, an essential transcription factor, is stimulated by the ERK-MAPK pathway.
Copyright © 2011 S. Karger AG, Basel
2011-06-01 00:00:00
Dentin matrix protein 1
ERK1/2 MAP kinase