10027/21480
Daesung Lee
Daesung
Lee
Rajdip Karmakar
Rajdip
Karmakar
Total Synthesis of Selaginpulvilin C and D Relying on in Situ Formation of Arynes and Their Hydrogenation
University of Illinois at Chicago
2017
untagged
2017-12-20 00:00:00
Journal contribution
https://indigo.uic.edu/articles/journal_contribution/Total_Synthesis_of_Selaginpulvilin_C_and_D_Relying_on_in_Situ_Formation_of_Arynes_and_Their_Hydrogenation/10768559
The total syntheses of selaginpulvilins C and D is described. The key strategy for the construction of the core fluorene moiety involves in situ formation of an aryne intermediate followed by its formal hydrogenation. The precursor tetraynes that undergo aromatization via hexadehydro Diels-Alder reaction were prepared from readily available building blocks through typical alkyne coupling reactions.