Utilizing the folate receptor for active
targeting of cancer nanotherapeutics
Grant L. Zwicke
G. Ali Mansoori
Constance J. Jeffery
10027/10858
https://indigo.uic.edu/articles/journal_contribution/Utilizing_the_folate_receptor_for_active_targeting_of_cancer_nanotherapeutics/10769714
The development of specialized nanoparticles for use in
the detection and treatment of cancer is increasing. Methods
are being proposed and tested that could target treatments
more directly to cancer cells, which could lead to higher
efficacy and reduced toxicity, possibly even eliminating the
adverse effects of damage to the immune system and the loss
of quick replicating cells. In this mini-review we focus on
recent studies that employ folate nanoconjugates to target
the folate receptor. Folate receptors are highly overexpressed
on the surface of many tumor types. This expression can be
exploited to target imaging molecules and therapeutic
compounds directly to cancerous tissues.
2013-12-06 00:00:00
cancer
conjugates
doxorubicin
folate
folic acid