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New Insights into the Specificity and Plasticity of Reward and Aversion Encoding in the Mesolimbic System
journal contribution
posted on 2016-04-11, 00:00 authored by Susan F. Volman, Stephan Lammel, Elyssa B. Margolis, Yunbok Kim, Jocelyn M. Richard, Mitchell F. Roitman, Mary Kay LoboThe mesocorticolimbic system, consisting, at its core, of the ventral tegmental area, the nucleus accumbens, and medial prefrontal cortex, has historically been investigated primarily for its role in positively motivated behaviors and reinforcement learning, and its dysfunction in addiction, schizophrenia, depression, and other mood disorders. Recently, researchers have undertaken a more comprehensive analysis of this system, including its role in not only reward but also punishment, as well as in both positive and negative reinforcement. This focus has been facilitated by new anatomical, physiological, and behavioral approaches to delineate functional circuits underlying behaviors and to determine how this system flexibly encodes and responds to positive and negative states and events, beyond simple associative learning. This review is a summary of topics covered in a mini-symposium at the 2013 Society for Neuroscience annual meeting.
Funding
This work was supported by National Institute on Drug Abuse Grant R01 DA030529 to E.B.M. and Grant R01 DA025634 to M.F.R., National Institute of Mental Health Grant R37 MH048404 to B. Mohgaddam, and Fellowship F31 MH090602 to J.M.R. The order of the authors reflects the order of their presentations in the SfN Minisymposium.
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Society for NeuroscienceLanguage
- en_US
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0270-6474Issue date
2013-11-01Usage metrics
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