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8q24 sequence variants in relation to prostate cancer risk among men of African descent: A case-control study

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posted on 12.05.2011, 00:00 by Marnita L. Benford, Tiva T. VanCleave, Nicole A. Lavender, Rick A. Kittles, LaCreis R. Kidd
Background: Human chromosome 8q24 has been implicated in prostate tumorigenesis. Methods: Consequently, we evaluated seven 8q24 sequence variants relative to prostate cancer (PCA) in a case-control study involving men of African descent. Genetic alterations were detected in germ-line DNA from 195 incident PCA cases and 531 controls using TaqMan polymerase chain reaction (PCR). Results: Inheritance of the 8q24 rs16901979 T allele corresponded to a 2.5-fold increase in the risk of developing PCA for our test group. These findings were validated using multifactor dimensionality reduction (MDR) and permutation testing (p = 0.038). The remaining 8q24 targets were not significantly related to PCA outcomes. Conclusions: Although compelling evidence suggests that the 8q24 rs16901979 locus may serve as an effective PCA predictor, our findings require additional evaluation in larger studies.

Funding

This study was supported in part by the NIH R03 CA128028, the James Graham Brown Cancer Center, and the Bucks for Brains "Our Highest Potential" in Cancer Research Endowment.

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Publisher Statement

The original source for this publication is at BioMed Central; DOI: 10.1186/1471-2407-10-334. © 2010 Benford et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Publisher

BioMed Central

Language

en_US

issn

1471-2407

Issue date

28/06/2010

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