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Activation of the ERK1/2 Mitogen-Activated Protein Kinase Cascade by Dentin Matrix Protein 1 Promotes Osteoblast Differentiation

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posted on 01.06.2011 by Asha S. Eapen, Amsaveni Ramachandran, Jitesh Pratap, Anne George
DMP1 has been shown to play many roles in osteogenesis. We recently demonstrated that calcium-mediated stress kinase activation by DMP1 leads to osteoblast differentiation. In this study we demonstrate that DMP1 can also activate the extracellular signal-regulated kinase (ERK)-MAPK pathway. This activation was mediated through the RGD integrin-binding domain in DMP1. Further, we demonstrate that Runx2, an essential transcription factor, is stimulated by the ERK-MAPK pathway. Copyright © 2011 S. Karger AG, Basel

Funding

This work was supported by National Institutes of Health Grant DE 11657 and by the Brodie Endowment Fund.

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Publisher Statement

Post print version of article may differ from published version. The definitive version is available through Karger at DOI: 10.1159/000324258 [http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000324258]. © 2011 S. Karger AG, Basel

Publisher

Karger

Language

en_US

issn

1422-6405

Issue date

06/05/2011

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