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Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease

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posted on 12.04.2016 by Andrew B. Wolf, Jon Valla, Guojun Bu, Jungsu Kim, Mary Jo LaDu, Eric M. Reiman, Richard J. Caselli
APOE, which encodes apolipoprotein E, is the most prevalent and best established genetic risk factor for late-onset Alzheimer’s disease. Current understanding of Alzheimer’s disease pathophysiology posits an important role for apolipoprotein E in the disease cascade via its interplay with β-amyloid. However, evidence is also emerging for roles of apolipoprotein E in the disease process that are independent of β-amyloid. Particular areas of interest are lipid metabolism, tau pathology, neuroenergetics, neurodevelopment, synaptic plasticity, the neurovasculature, and neuroinflammation. The intent of this article is to review the literature in each of these areas.

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Funding

This work was supported by the Arizona Alzheimer’s Consortium, the State of Arizona, the Arizona Alzheimer’s Disease Core Center (P30 AG19610), and the University of Colorado Medical Scientist Training Program (NIGMS 5T32GM008497-20).

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Publisher

BioMed Central

Language

en_US

issn

1758-9193

Issue date

01/01/2013

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