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Byrsonima fagifolia Niedenzu Apolar Compounds with Antitubercular Activity

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posted on 16.08.2012 by C. Higuchi, M. Sannomiya, F. Pavan, S. Leite, D. Sato, S. Franzblau, L.V. Sacramento, W. Vilegas, C. Leite
Bioassay-guided fractionation of the chloroform extract of Byrsonima fagifolia leaves led to the isolation of active antitubercular compounds alkane dotriacontane (Minimal Inhibitory Concentration-MIC, 62.5 mu g mL(-1)), triterpenoids as bassic acid (MIC = 2.5 mu g mL(-1)), alpha-amyrin acetate (MIC = 62.5 mu g mL(-1)), a mixture of lupeol, alpha- and beta-amyrin (MIC = 31.5 mu g mL(-1)) and a mixture of lupeol, and acetates of alpha- and beta-amyrin (MIC = 31.5 mu g mL(-1)). The antimycobacterial activity was determined by the Microplate Alamar Blue Assay (MABA) and the structures of promising compounds were determined by spectroscopic analysis. This investigation constitutes the first report of a chemical and antitubercular study of apolar compounds from B. fagifolia Niedenzu (IK).

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Funding

The authors thank the Fundac¸˜ao de Amparo `a Pesquisa do Estado de S˜ao Paulo (FAPESP) for a grant to Miriam Sannomiya and Fernando Rog´erio Pavan, and for funding of the project Biota-Fapesp 02/05503-6. They also thank CNPq for a grant to W. Vilegas.

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Publisher Statement

Copyright © 2011 C. T. Higuchi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: 10.1093/ecam/nen077

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Hindawi Publishing Corporation

Language

en_US

issn

1741-427X

Issue date

01/01/2011

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