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CASTp 3.0: Computed Atlas of Surface Topography of proteins

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posted on 15.01.2019 by Wei Tian, Chen Chang, Xue Lei, Jieling Zhao
Geometric and topological properties of protein structures, including surface pockets, interior cavities and cross channels, are of fundamental importance for proteins to carry out their functions. Computed Atlas of Surface Topography of proteins (CASTp) is a web server that provides online services for locating, delineating and measuring these geometric and topological properties of protein structures. It has been widely used since its inception in 2003. In this article, we present the latest version of the web server, CASTp 3.0. CASTp 3.0 continues to provide reliable and comprehensive identifications and quantifications of protein topography. In addition, it now provides: (i) imprints of the negative volumes of pockets, cavities and channels, (ii) topographic features of biological assemblies in the Protein Data Bank, (iii) improved visualization of protein structures and pockets, and (iv) more intuitive structural and annotated information, including information of secondary structure, functional sites, variant sites and other annotations of protein residue

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Funding

This work was supported by NIH grant R01CA204962.

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Publisher Statement

This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Nucleic Acids Research following peer review. The definitive publisher-authenticated version Tian, W., Chen, C., Lei, X., Zhao, J. L., & Liang, J. (2018). CASTp 3.0: computed atlas of surface topography of proteins. Nucleic Acids Research, 46(W1), W363-W3 is available online at: doi:10.1093/nar/gky473.

Citation

Tian, W., Chen, C., Lei, X., Zhao, J. L., & Liang, J. (2018). CASTp 3.0: computed atlas of surface topography of proteins. Nucleic Acids Research, 46(W1), W363-W367. doi:10.1093/nar/gky473

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Oxford University Press

Language

en_US

issn

0305-1048

Issue date

02/06/2018

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